Table 4 Effects of covariates on seizure occurrence or rate (SANAD)
From: Guide to evaluating performance of prediction models for recurrent clinical events
Variable | NB: OR (95% CI) | ZINB logit: OR (95% CI) | ZINB count: RR (95% CI) | AG: HR (95% CI) | PWP-TT: HR (95% CI) | |
|---|---|---|---|---|---|---|
Intercept | 6.54 (5.66, 7.47) | 2.23 (1.24, 3.25) | 6.31 (5.583, 7.08) | N/A | N/A | |
Gender | Female | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Male | 1.15 (0.79, 1.67) | 0.60 (0.41, 0.88) | 1.37 (1.00, 1.88) | 1.31 (0.90, 1.91) | 1.09 (1.00, 1.20) | |
Primary relative with epilepsy | Absent | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Present | 2.10 (1.36, 3.37) | 2.00 (1.21, 3.42) | 1.83 (1.28, 2.68) | 1.74 (1.07, 2.81) | 1.09 (0.96, 1.24) | |
Treatment | Valproate | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Lamotrigine | 1.74 (1.13, 2.69) | 1.83 (1.18, 2.85) | 1.52 (1.05, 2.21) | 2.01 (1.27, 3.18) | 1.14 (1.02, 1.27) | |
Topiramate | 1.55 (1.01, 2.39) | 1.33 (0.87, 2.03) | 1.55 (1.06, 2.26) | 1.92 (1.18, 3.12) | 1.17 (1.03, 1.31) | |
Age at randomisation (years) | 0.28 (0.21, 0.37) | 0.44 (0.32, 0.60) | 0.34 (0.27, 0.43) | 0.36 (0.24, 0.53) | 0.90 (0.83, 0.98) | |
Annual tonic–clonic seizure rate prior to randomisation | 0.86 (0.81, 0.91) | 0.96 (0.89, 1.03) | 0.86 (0.82, 0.90) | 0.88 (0.81, 0.95) | 1.02 (1.00, 1.03) | |