Skip to main content

Table 3 Effects of covariates on exacerbation occurrence or rate (OPCRD)

From: Guide to evaluating performance of prediction models for recurrent clinical events

Variable

Level

NB: OR (95% CI)

ZINB logit: OR (95% CI)

ZINB count: RR (95% CI)

AG: HR (95% CI)

PWP-TT: HR (95% CI)

Intercept

 − 8.50 (− 8.59, − 8.41)

 − 5.21 (− 5.57, − 4.86)

 − 7.55 (− 7.68, − 7.42)

N/A

N/A

Age (log*)

1.41 (1.38, 1.44)

0.75 (0.69, 0.82)

1.28 (1.24, 1.32)

1.42 (1.40, 1.44)

1.30 (1.29, 1.32)

Gender

Female

1.00

1.00

1.00

1.00

1.00

Male

0.74 (0.72, 0.75)

1.52 (1.40, 1.65)

0.82 (0.80, 0.84)

0.77 (0.76, 0.78)

0.83 (0.82, 0.84)

Previous exacerbations

No

1.00

1.00

1.00

1.00

1.00

Yes

2.01 (1.97, 2.06)

0.32 (0.29, 0.35)

1.40 (1.35, 1.45)

1.46 (1.44, 1.49)

1.30 (1.28, 1.31)

Smoking status

Non-smoker

1.00

1.00

1.00

1.00

1.00

Current smoker

1.32 (1.29, 1.36)

0.72 (0.65, 0.80)

1.23 (1.19, 1.27)

1.26 (1.23, 1.28)

1.18 (1.16, 1.19)

Ex-smoker

1.13 (1.10, 1.16)

0.90 (0.82, 0.99)

1.10 (1.07, 1.14)

1.09 (1.07, 1.11)

1.06 (1.05, 1.07)

Year of entry into study

2013

1.00

1.00

1.00

1.00

1.00

2005

1.16 (1.06, 1.28)

1.14 (0.81, 1.62)

1.21 (1.06, 1.37)

1.35 (1.27, 1.44)

1.25 (1.20, 1.31)

2006

1.22 (1.16, 1.28)

0.71 (0.57, 0.89)

1.12 (1.05, 1.19)

1.30 (1.25, 1.34)

1.21 (1.18, 1.24)

2007

1.27 (1.19, 1.35)

0.80 (0.62, 1.04)

1.21 (1.11, 1.30)

1.27 (1.22, 1.33)

1.18 (1.14, 1.21)

2008

1.09 (1.05, 1.14)

0.78 (0.65, 0.93)

1.03 (0.97, 1.09)

1.05 (1.01, 1.08)

1.02 (1.00, 1.05)

2009

1.05 (1.01, 1.10)

0.78 (0.66, 0.93)

0.99 (0.94, 1.05)

0.99 (0.96, 1.02)

0.99 (0.97, 1.01)

2010

1.09 (1.05, 1.14)

0.83 (0.70, 0.98)

1.04 (0.99, 1.10)

1.04 (1.01, 1.07)

1.02 (1.00, 1.04)

2011

1.05 (1.05, 1.09)

0.85 (0.73, 1.00)

1.01 (0.96, 1.06)

1.04 (1.01, 1.07)

1.02 (1.00, 1.04)

2012

1.06 (1.03, 1.10)

1.01 (0.87, 1.16)

1.07 (1.02, 1.12)

1.01 (0.98, 1.04)

0.99 (0.97, 1.01)

  1. NB negative binomial, ZINB zero-inflated negative binomial, AG Andersen-Gill, PWP-TT Prentice, Williams and Peterson total time, RR relative risk, OR odds ratio, HR hazard ratio
  2. *Log transformation identified through multivariable fractional polynomial procedure where applicable